Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM030755-19A2
Application #
6399530
Study Section
Special Emphasis Panel (ZRG1-SSS-M (02))
Program Officer
Chin, Jean
Project Start
1981-09-01
Project End
2005-05-31
Budget Start
2001-06-01
Budget End
2002-05-31
Support Year
19
Fiscal Year
2001
Total Cost
$320,050
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Redmond, Robert W; Kochevar, Irene E (2006) Spatially resolved cellular responses to singlet oxygen. Photochem Photobiol 82:1178-86
Valencia, Antonio; Rajadurai, Anpuchchelvi; Carle, A Bjorn et al. (2006) 7-Dehydrocholesterol enhances ultraviolet A-induced oxidative stress in keratinocytes: roles of NADPH oxidase, mitochondria, and lipid rafts. Free Radic Biol Med 41:1704-18
Zhuang, Shougang; Ouedraogo, Gladys D; Kochevar, Irene E (2003) Downregulation of epidermal growth factor receptor signaling by singlet oxygen through activation of caspase-3 and protein phosphatases. Oncogene 22:4413-24
Zhuang, Shougang; Kochevar, Irene E (2003) Ultraviolet A radiation induces rapid apoptosis of human leukemia cells by Fas ligand-independent activation of the Fas death pathways. Photochem Photobiol 78:61-7
Zhuang, Shougang; Kochevar, Irene E (2003) Singlet oxygen-induced activation of Akt/protein kinase B is independent of growth factor receptors. Photochem Photobiol 78:361-71
Zhuang, S; Demirs, J T; Kochevar, I E (2001) Protein kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation. Oncogene 20:6764-76
Kochevar, I E; Redmond, R W (2000) Photosensitized production of singlet oxygen. Methods Enzymol 319:20-8
Lin, C P; Lynch, M C; Kochevar, I E (2000) Reactive oxidizing species produced near the plasma membrane induce apoptosis in bovine aorta endothelial cells. Exp Cell Res 259:351-9
Kochevar, I E; Lynch, M C; Zhuang, S et al. (2000) Singlet oxygen, but not oxidizing radicals, induces apoptosis in HL-60 cells. Photochem Photobiol 72:548-53
Tartier, L; McCarey, Y L; Biaglow, J E et al. (2000) Apoptosis induced by dithiothreitol in HL-60 cells shows early activation of caspase 3 and is independent of mitochondria. Cell Death Differ 7:1002-10

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