Abstract

This proposal describes a continuation of a program directed towards the total synthesis of brevetoxin B. The major thrusts of the program will focus on (a) new synthetic technology for the construction of the octacycle of brevetoxin B, (b) new synthetic technology for the construction of the heptacycles of brevetoxin B, (c) completion of the total synthesis of the target molecule and (d) synthesis of a number of models and analogs of brevetoxin B for biological investigations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM031398-04
Application #
3279382
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1983-01-01
Project End
1989-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Nicolaou, K C (2009) Inspirations, discoveries, and future perspectives in total synthesis. J Org Chem 74:951-72
Gawley, R E; Rein, K S; Jeglitsch, G et al. (1995) The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels. Chem Biol 2:533-41
Erickson, A H (1989) Biosynthesis of lysosomal endopeptidases. J Cell Biochem 40:31-41