This proposal describes a continuation of a program directed towards the total synthesis of brevetoxin B. The major thrusts of the program will focus on (a) new synthetic technology for the construction of the octacycle of brevetoxin B, (b) new synthetic technology for the construction of the heptacycles of brevetoxin B, (c) completion of the total synthesis of the target molecule and (d) synthesis of a number of models and analogs of brevetoxin B for biological investigations.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM031398-08
Application #
3279390
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1989-09-01
Project End
1989-12-31
Budget Start
1989-09-01
Budget End
1989-12-31
Support Year
8
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037
Nicolaou, K C (2009) Inspirations, discoveries, and future perspectives in total synthesis. J Org Chem 74:951-72
Gawley, R E; Rein, K S; Jeglitsch, G et al. (1995) The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels. Chem Biol 2:533-41
Erickson, A H (1989) Biosynthesis of lysosomal endopeptidases. J Cell Biochem 40:31-41