Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM031555-07
Application #
3279640
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1983-12-01
Project End
1990-04-30
Budget Start
1989-12-01
Budget End
1990-04-30
Support Year
7
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Whalen, Richard; Liu, Xiangdang; Boyer, Thomas D (2006) Identification of a short form of ubiquitin-specific protease 3 that is a repressor of rat glutathione S-transferase gene expression. Biochem J 394:519-26
Ranganathan, Perungavar N; Whalen, Richard; Boyer, Thomas D (2005) Characterization of the molecular forms of glutathione S-transferase P1 in human gastric cancer cells (Kato III) and in normal human erythrocytes. Biochem J 386:525-33
Whalen, Richard; Voss, Susan H; Boyer, Thomas D (2004) Decreased expression levels of rat liver glutathione S-transferase A2 and albumin during the acute phase response are mediated by HNF1 (hepatic nuclear factor 1) and IL6DEX-NP. Biochem J 377:763-8
Voss, Susan H; Whalen, Richard; Boyer, Thomas D (2002) Mechanism of negative regulation of rat glutathione S-transferase A2 by the cytokine interleukin 6. Biochem J 365:229-37
Selim, N; Branum, G D; Liu, X et al. (2000) Differential lobular induction in rat liver of glutathione S-transferase A1/A2 by phenobarbital. Am J Physiol Gastrointest Liver Physiol 278:G542-50
Whalen, R; Rockey, D C; Friedman, S L et al. (1999) Activation of rat hepatic stellate cells leads to loss of glutathione S-transferases and their enzymatic activity against products of oxidative stress. Hepatology 30:927-33
Whalen, R; Boyer, T D (1998) Human glutathione S-transferases. Semin Liver Dis 18:345-58
Branum, G D; Selim, N; Liu, X et al. (1998) Ischaemia and reperfusion injury of rat liver increases expression of glutathione S-transferase A1/A2 in zone 3 of the hepatic lobule. Biochem J 330 ( Pt 1):73-9
Voss, S H; Park, Y; Kwon, S O et al. (1996) Role of interleukin 6 and corticosteroids in the regulation of expression of glutathione S-transferases in primary cultures of rat hepatocytes. Biochem J 317 ( Pt 2):627-32
Whalen, R; Kempner, E S; Boyer, T D (1996) Structural studies of a human pi class glutathione S-transferase. Photoaffinity labeling of the active site and target size analysis. Biochem Pharmacol 52:281-8

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