Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM031756-15
Application #
2176303
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1982-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Type
Organized Research Units
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Denisov, Ilia G; Sligar, Stephen G (2017) Nanodiscs in Membrane Biochemistry and Biophysics. Chem Rev 117:4669-4713
Marty, Michael T; Zhang, Hao; Cui, Weidong et al. (2014) Interpretation and deconvolution of nanodisc native mass spectra. J Am Soc Mass Spectrom 25:269-77
Mak, Piotr J; Luthra, Abhinav; Sligar, Stephen G et al. (2014) Resonance Raman spectroscopy of the oxygenated intermediates of human CYP19A1 implicates a compound i intermediate in the final lyase step. J Am Chem Soc 136:4825-8
Khatri, Yogan; Gregory, Michael C; Grinkova, Yelena V et al. (2014) Active site proton delivery and the lyase activity of human CYP17A1. Biochem Biophys Res Commun 443:179-84
Khatri, Yogan; Luthra, Abhinav; Duggal, Ruchia et al. (2014) Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps. FEBS Lett 588:3117-22
Mak, Piotr J; Gregory, Michael C; Sligar, Stephen G et al. (2014) Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17. Biochemistry 53:90-100
Sloan, Courtney D Kuhnline; Marty, Michael T; Sligar, Stephen G et al. (2013) Interfacing lipid bilayer nanodiscs and silicon photonic sensor arrays for multiplexed protein-lipid and protein-membrane protein interaction screening. Anal Chem 85:2970-6
Gregory, Michael; Mak, Piotr J; Sligar, Stephen G et al. (2013) Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry. Angew Chem Int Ed Engl 52:5342-5
Gregory, Michael C; Denisov, Ilia G; Grinkova, Yelena V et al. (2013) Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate. J Am Chem Soc 135:16245-7
Sun, Yuhan; Zeng, Weiqiao; Benabbas, Abdelkrim et al. (2013) Investigations of heme ligation and ligand switching in cytochromes p450 and p420. Biochemistry 52:5941-51

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