Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM031973-14S1
Application #
2397613
Study Section
Biochemistry Study Section (BIO)
Project Start
1983-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
14
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Huehls, Amelia M; Huntoon, Catherine J; Joshi, Poorval M et al. (2016) Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination. Mol Pharmacol 89:53-62
Darzynkiewicz, Zbigniew; Zhao, Hong; Zhang, Sufang et al. (2015) Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase ? revealed in individual cells by cytometry. Oncotarget 6:11735-50
Lee, Marietta Y W T; Zhang, Sufang; Lin, Szu Hua Sharon et al. (2014) The tail that wags the dog: p12, the smallest subunit of DNA polymerase ?, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression. Cell Cycle 13:23-31
Zhao, Hong; Zhang, Sufang; Xu, Dazhong et al. (2014) Expression of the p12 subunit of human DNA polymerase ? (Pol ?), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells. Cell Cycle 13:3529-40
Zhang, Sufang; Zhao, Hong; Darzynkiewicz, Zbiegniew et al. (2013) A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase ? in response to DNA damage and during the S phase. J Biol Chem 288:29550-61
Zhang, Sufang; Zhou, Yajing; Sarkeshik, Ali et al. (2013) Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase ? for degradation in response to DNA damage. J Biol Chem 288:2941-50
Walsh, Erin; Wang, Xiaoxiao; Lee, Marietta Y et al. (2013) Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication. J Mol Biol 425:232-43
Wong, Agnes; Zhang, Sufang; Mordue, Dana et al. (2013) PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2. Cell Cycle 12:3184-93
Clausen, Anders R; Zhang, Sufang; Burgers, Peter M et al. (2013) Ribonucleotide incorporation, proofreading and bypass by human DNA polymerase ?. DNA Repair (Amst) 12:121-7
Lin, Szu Hua Sharon; Wang, Xiaoxiao; Zhang, Sufang et al. (2013) Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase ?. DNA Repair (Amst) 12:922-35

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