Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM032095-13A2
Application #
2176426
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1982-04-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Austin
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712
Molineux, Ian J; Panja, Debabrata (2013) Popping the cork: mechanisms of phage genome ejection. Nat Rev Microbiol 11:194-204
Casjens, Sherwood R; Molineux, Ian J (2012) Short noncontractile tail machines: adsorption and DNA delivery by podoviruses. Adv Exp Med Biol 726:143-79
Nguyen, Andre H; Molineux, Ian J; Springman, Rachael et al. (2012) Multiple genetic pathways to similar fitness limits during viral adaptation to a new host. Evolution 66:363-74
Lee, Young-Sam; Johnson, Kenneth A; Molineux, Ian J et al. (2010) A single mutation in human mitochondrial DNA polymerase Pol gammaA affects both polymerization and proofreading activities of only the holoenzyme. J Biol Chem 285:28105-16
Savalia, Dhruti; Robins, William; Nechaev, Sergei et al. (2010) The role of the T7 Gp2 inhibitor of host RNA polymerase in phage development. J Mol Biol 402:118-26
Chang, Chung-Yu; Kemp, Priscilla; Molineux, Ian J (2010) Gp15 and gp16 cooperate in translocating bacteriophage T7 DNA into the infected cell. Virology 398:176-86
Bull, J J; Vimr, E R; Molineux, I J (2010) A tale of tails: Sialidase is key to success in a model of phage therapy against K1-capsulated Escherichia coli. Virology 398:79-86
Lee, Young-Sam; Lee, Sujin; Demeler, Borries et al. (2010) Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity. J Biol Chem 285:1490-9
Panja, Debabrata; Molineux, Ian J (2010) Dynamics of bacteriophage genome ejection in vitro and in vivo. Phys Biol 7:045006
Keller, Thomas E; Molineux, Ian J; Bull, James J (2009) Viral resistance evolution fully escapes a rationally designed lethal inhibitor. Mol Biol Evol 26:2041-6

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