Abstract

The objectives of this research proposal have been divided into three sections. Part I deals with the completion of currently funded work on total synthesis of the antitumor antibiotic echinosporin. Part II is concerned with applications of the intramolecular Kondrat'eva pyridine synthesis to natural products such as the cytotoxic marine metabolite amphimedine and some momoterpenoid pyridine alkaloids. Part III of the proposal describes exploratory methodological studies of metal catalyzed intramolecular free radical cyclizations of Alpha,Alpha-dichloroesters and related compounds to produce highly functionalized ring systems. These synthetic studies will hopefully make available compounds with potential as antitumor agents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM032299-11
Application #
3281008
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1978-09-01
Project End
1990-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
11
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Type
Schools of Arts and Sciences
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802