Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM032304-12
Application #
2176517
Study Section
Special Emphasis Panel (ZRG4-PHRA (01))
Project Start
1984-07-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Sahu, Mukesh; Sharma, Rajendra; Yadav, Sushma et al. (2014) Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia. Exp Eye Res 118:125-34
Yadav, Sushma; Zajac, Ewa; Singhal, Sharad S et al. (2005) POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. Biochem Biophys Res Commun 328:1003-9
Sharma, Rajendra; Yang, Yusong; Sharma, Abha et al. (2004) Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxid Redox Signal 6:289-300
Yang, Yongzhen; Yang, Yusong; Trent, Margaret B et al. (2004) Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis. Atherosclerosis 173:211-21
Sharma, Rajendra; Awasthi, Yogesh C; Yang, Yusong et al. (2003) Energy dependent transport of xenobiotics and its relevance to multidrug resistance. Curr Cancer Drug Targets 3:89-107
Awasthi, Sanjay; Singhal, Sharad S; Sharma, Rajendra et al. (2003) Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance. Int J Cancer 106:635-46
Awasthi, Yogesh C; Sharma, Rajendra; Cheng, J Z et al. (2003) Role of 4-hydroxynonenal in stress-mediated apoptosis signaling. Mol Aspects Med 24:219-30
Sharma, Rajendra; Yang, Yusong; Sharma, Abha et al. (2003) Mechanisms and physiological significance of the transport of the glutathione conjugate of 4-hydroxynonenal in human lens epithelial cells. Invest Ophthalmol Vis Sci 44:3438-49
Awasthi, Sanjay; Singhal, Sharad S; Singhal, Jyotsana et al. (2003) Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76. Int J Oncol 22:713-20
Singhal, Sharad S; Singhal, Jyotsana; Sharma, Rajendra et al. (2003) Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. Int J Oncol 22:365-75

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