Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM032634-17
Application #
2176671
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1983-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201

  Publications

Vintem, Ana Paula B; Price, Nigel T; Silverman, Richard B et al. (2005) Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines. Bioorg Med Chem 13:3487-95
Schering, Christine A; Zhong, Boyu; Woo, Jonathan C G et al. (2004) Poly(ethylene glycol)-supported enzyme inactivators. Efficient identification of the site of covalent attachment to alpha-chymotrypsin by PEG-TPCK. Bioconjug Chem 15:673-6
Lu, Xingliang; Rodriguez, Maria; Gu, Wenxin et al. (2003) Inactivation of mitochondrial monoamine oxidase B by methylthio-substituted benzylamines. Bioorg Med Chem 11:4423-30
Lu, Xingliang; Nikolic, Dejan; Mitchell, Deanna J et al. (2003) A mechanism for substrate-Induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase. Bioorg Med Chem Lett 13:4129-32
Lee, Younghee; Ling, Ke-Qing; Lu, Xingliang et al. (2002) 3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases. J Am Chem Soc 124:12135-43
Mitchell, D J; Nikolic, D; van Breemen, R B et al. (2001) Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: mass spectral evidence for the flavin adduct. Bioorg Med Chem Lett 11:1757-60
Mitchell, D J; Nikolic, D; Rivera, E et al. (2001) Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N. Biochemistry 40:5447-56
Mitchell, D J; Nikolic, D; Jang, M H et al. (2001) Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine. Biochemistry 40:8523-30
Woodroofe, C C; Mostashari, R; Lu, X et al. (2000) Selective inhibition of monoamine oxidase B by aminoethyl substituted benzyl ethers. J Enzyme Inhib 15:21-Nov
Wang, X; Silverman, R B (2000) Monoamine oxidase-catalyzed oxidation of endo,endo-2-amino-6-[(Z)-2'-phenyl]ethenylbicyclo[2.2.1]heptane, a potential probe for a radical cation intermediate. Bioorg Med Chem 8:1645-51

Showing the most recent 10 out of 37 publications