It is planned to complete the total synthesis of strychnine 18. The development of kinetic enol chemistry using triisopropylsilyl enol ether is to be studied with the emphasis on the direct amination of ketones. Illustrations of the potential utility of the amination chemistry is to be examined, and they include short routes to methyl homodaphniphyllate 78, benzomorphane systems 101, the anti-Alzheimers compound huperzine 111. Some general scope and limitation studies are planned. A mu-cyclophane strategy for the synthesis of the teleocidins tumor promoters is described.
| Cheung, Chi-Ming; Goldberg, Frederick W; Magnus, Philip et al. (2007) An expedient formal total synthesis of (-)-diazonamide A via a powerful, stereoselective O-aryl to C-aryl migration to form the C10 quaternary center. J Am Chem Soc 129:12320-7 |
| Black, Phillip J; Hecker, Evan A; Magnus, Philip (2007) Studies towards the synthesis of the marine alkaloid chartelline C. Tetrahedron Lett 48:6364-6367 |
| Magnus, Philip; Matthews, Kenneth S; Lynch, Vince (2003) New strategy for the synthesis of tetrahydroisoquinoline alkaloids. Org Lett 5:2181-4 |
