Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM032741-14
Application #
2176725
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1983-12-01
Project End
1999-11-30
Budget Start
1995-12-05
Budget End
1996-11-30
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Genetics
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Fischer, Jared M; Dudley, Sandra; Miller, Ashleigh J et al. (2016) An intact Pms2 ATPase domain is not essential for male fertility. DNA Repair (Amst) 39:46-51
Fischer, Jared M; Calabrese, Peter P; Miller, Ashleigh J et al. (2016) Single cell lineage tracing reveals a role for Tgf?R2 in intestinal stem cell dynamics and differentiation. Proc Natl Acad Sci U S A 113:12192-12197
Fischer, Jared M; Schepers, Arnout G; Clevers, Hans et al. (2014) Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. Carcinogenesis 35:237-46
Fischer, J M; Miller, A J; Shibata, D et al. (2012) Different phenotypic consequences of simultaneous versus stepwise Apc loss. Oncogene 31:2028-38
Johnson, Jennifer R; Erdeniz, Naz; Nguyen, Megan et al. (2010) Conservation of functional asymmetry in the mammalian MutL? ATPase. DNA Repair (Amst) 9:1209-13
Tsao, Jen-Lan; Dudley, Sandra; Kwok, Brian et al. (2002) Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis 23:1807-10
Baross-Francis, A; Makhani, N; Liskay, R M et al. (2001) Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells. Oncogene 20:619-25
Yao, X; Buermeyer, A B; Narayanan, L et al. (1999) Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proc Natl Acad Sci U S A 96:6850-5
Buermeyer, A B; Wilson-Van Patten, C; Baker, S M et al. (1999) The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts. Cancer Res 59:538-41
Winter, D B; Phung, Q H; Umar, A et al. (1998) Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2. Proc Natl Acad Sci U S A 95:6953-8

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