Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM033143-11
Application #
2176872
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1983-07-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Higgins, N Patrick (2016) Species-specific supercoil dynamics of the bacterial nucleoid. Biophys Rev 8:113-121
Higgins, N Patrick; Vologodskii, Alexander V (2015) Topological Behavior of Plasmid DNA. Microbiol Spectr 3:
Higgins, N Patrick (2014) RNA polymerase: chromosome domain boundary maker and regulator of supercoil density. Curr Opin Microbiol 22:138-43
Higgins, N Patrick (2012) A human TOP2A core DNA binding X-ray structure reveals topoisomerase subunit dynamics and a potential mechanism for SUMO modulation of decatenation. J Mol Biol 424:105-8
Rovinskiy, Nikolay; Agbleke, Andrews Akwasi; Chesnokova, Olga et al. (2012) Rates of gyrase supercoiling and transcription elongation control supercoil density in a bacterial chromosome. PLoS Genet 8:e1002845
Booker, Betty M; Deng, Shuang; Higgins, N Patrick (2010) DNA topology of highly transcribed operons in Salmonella enterica serovar Typhimurium. Mol Microbiol 78:1348-64
Manna, Dipankar; Porwollik, Steffen; McClelland, Michael et al. (2007) Microarray analysis of Mu transposition in Salmonella enterica, serovar Typhimurium: transposon exclusion by high-density DNA binding proteins. Mol Microbiol 66:315-28
Champion, Keith; Higgins, N Patrick (2007) Growth rate toxicity phenotypes and homeostatic supercoil control differentiate Escherichia coli from Salmonella enterica serovar Typhimurium. J Bacteriol 189:5839-49
Higgins, N Patrick (2007) Under DNA stress, gyrase makes the sign of the cross. Nat Struct Mol Biol 14:256-8
Higgins, N Patrick (2007) Mutational bias suggests that replication termination occurs near the dif site, not at Ter sites: what's the Dif? Mol Microbiol 64:1-4

Showing the most recent 10 out of 34 publications