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Kaur, Parminder; Chamberlin, A Richard; Poulos, Thomas L et al. (2016) Structure-Based Inhibitor Design for Evaluation of a CYP3A4 Pharmacophore Model. J Med Chem 59:4210-20
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Poulos, Thomas L (2014) Heme enzyme structure and function. Chem Rev 114:3919-62
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Sevrioukova, Irina F; Poulos, Thomas L (2014) Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanism. Curr Top Med Chem 14:1348-55
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Madrona, Yarrow; Hollingsworth, Scott A; Tripathi, Sarvind et al. (2014) Crystal structure of cindoxin, the P450cin redox partner. Biochemistry 53:1435-46
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Poulos, Thomas L; Madrona, Yarrow (2013) Oxygen activation and redox partner binding in cytochromes P450. Biotechnol Appl Biochem 60:128-33
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Batabyal, Dipanwita; Poulos, Thomas L (2013) Crystal structures and functional characterization of wild-type CYP101D1 and its active site mutants. Biochemistry 52:8898-906
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Sevrioukova, Irina F; Poulos, Thomas L (2013) Dissecting cytochrome P450 3A4-ligand interactions using ritonavir analogues. Biochemistry 52:4474-81
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Sevrioukova, Irina F; Poulos, Thomas L (2013) Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir. J Med Chem 56:3733-41
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Madrona, Yarrow; Hollingsworth, Scott A; Khan, Bushra et al. (2013) P450cin active site water: implications for substrate binding and solvent accessibility. Biochemistry 52:5039-50
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Sevrioukova, Irina F; Poulos, Thomas L (2013) Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems. Dalton Trans 42:3116-26
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Showing the most recent 10 out of 68 publications
