Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM033775-12
Application #
2177127
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1984-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Mak, Piotr J; Duggal, Ruchia; Denisov, Ilia G et al. (2018) Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone. J Am Chem Soc 140:7324-7331
Denisov, Ilia G; Sligar, Stephen G (2017) Nanodiscs in Membrane Biochemistry and Biophysics. Chem Rev 117:4669-4713
Ye, Xin; McLean, Mark A; Sligar, Stephen G (2016) Phosphatidylinositol 4,5-Bisphosphate Modulates the Affinity of Talin-1 for Phospholipid Bilayers and Activates Its Autoinhibited Form. Biochemistry 55:5038-48
Denisov, Ilia G; Mak, Piotr J; Grinkova, Yelena V et al. (2016) The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4. J Inorg Biochem 158:77-85
Reichart, Timothy M; Baksh, Michael M; Rhee, Jin-Kyu et al. (2016) Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding. Angew Chem Int Ed Engl 55:2688-92
Carney, Christiane E; Lenov, Ivan L; Baker, Catherine J et al. (2015) Nanodiscs as a Modular Platform for Multimodal MR-Optical Imaging. Bioconjug Chem 26:899-905
Skar-Gislinge, Nicholas; Kynde, Søren A R; Denisov, Ilia G et al. (2015) Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment. Acta Crystallogr D Biol Crystallogr 71:2412-21
Denisov, Ilia G; Grinkova, Yelena V; Baylon, Javier L et al. (2015) Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomer. Biochemistry 54:2227-39
Mak, Piotr J; Gregory, Michael C; Denisov, Ilia G et al. (2015) Unveiling the crucial intermediates in androgen production. Proc Natl Acad Sci U S A 112:15856-61
Wilcox, Kyle C; Marunde, Matthew R; Das, Aditi et al. (2015) Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated A? Oligomers. PLoS One 10:e0125263

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