Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM034360-11
Application #
2177395
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1985-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Weizmann Institute of Science
Department
Type
DUNS #
City
Rehovot
State
Country
Israel
Zip Code
76100
Krupkin, Miri; Wekselman, Itai; Matzov, Donna et al. (2016) Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding. Proc Natl Acad Sci U S A 113:E6796-E6805
Auerbach-Nevo, Tamar; Baram, David; Bashan, Anat et al. (2016) Ribosomal Antibiotics: Contemporary Challenges. Antibiotics (Basel) 5:
Belousoff, Matthew J; Shapira, Tal; Bashan, Anat et al. (2011) Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit. Proc Natl Acad Sci U S A 108:2717-22
Krupkin, Miri; Matzov, Donna; Tang, Hua et al. (2011) A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome. Philos Trans R Soc Lond B Biol Sci 366:2972-8
Auerbach, Tamar; Mermershtain, Inbal; Davidovich, Chen et al. (2010) The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics. Proc Natl Acad Sci U S A 107:1983-8
Yonath, Ada (2010) Polar bears, antibiotics, and the evolving ribosome (Nobel Lecture). Angew Chem Int Ed Engl 49:4341-54
Davidovich, Chen; Belousoff, Matthew; Wekselman, Itai et al. (2010) The Proto-Ribosome: an ancient nano-machine for peptide bond formation. Isr J Chem 50:29-35
Belousoff, Matthew J; Davidovich, Chen; Zimmerman, Ella et al. (2010) Ancient machinery embedded in the contemporary ribosome. Biochem Soc Trans 38:422-7
Davidovich, Chen; Belousoff, Matthew; Bashan, Anat et al. (2009) The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery. Res Microbiol 160:487-92
Wekselman, Itai; Davidovich, Chen; Agmon, Ilana et al. (2009) Ribosome's mode of function: myths, facts and recent results. J Pept Sci 15:122-30

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