Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM034496-03S1
Application #
3285597
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1984-12-01
Project End
1988-02-29
Budget Start
1986-12-01
Budget End
1988-02-29
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Yao, Jiangwei; Rock, Charles O (2018) Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis. Front Microbiol 9:2291
Honsa, Erin S; Cooper, Vaughn S; Mhaissen, Mohammed N et al. (2017) RelA Mutant Enterococcus faecium with Multiantibiotic Tolerance Arising in an Immunocompromised Host. MBio 8:
Robertson, Rosanna M; Yao, Jiangwei; Gajewski, Stefan et al. (2017) A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer. Nat Struct Mol Biol 24:666-671
Arensdorf, Angela M; Dillard, Miriam E; Menke, Jacob M et al. (2017) Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation. Cell Rep 19:2074-2087
Ericson, Megan E; Subramanian, Chitra; Frank, Matthew W et al. (2017) Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in Staphylococcus aureus. MBio 8:
Yao, Jiangwei; Rock, Charles O (2017) Bacterial fatty acid metabolism in modern antibiotic discovery. Biochim Biophys Acta Mol Cell Biol Lipids 1862:1300-1309
Yao, Jiangwei; Rock, Charles O (2017) Exogenous fatty acid metabolism in bacteria. Biochimie 141:30-39
Yao, Jiangwei; Bruhn, David F; Frank, Matthew W et al. (2016) Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria. J Biol Chem 291:171-81
Subramanian, Chitra; Yun, Mi-Kyung; Yao, Jiangwei et al. (2016) Allosteric Regulation of Mammalian Pantothenate Kinase. J Biol Chem 291:22302-22314
Yao, Jiangwei; Rock, Charles O (2016) Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics. Cold Spring Harb Perspect Med 6:a027045

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