Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM034690-13
Application #
2177534
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1988-06-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Surgery
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Tomasevic, Gregor; Laurer, Helmut L; Mattiasson, Gustav et al. (2012) Delayed neuromotor recovery and increased memory acquisition dysfunction following experimental brain trauma in mice lacking the DNA repair gene XPA. J Neurosurg 116:1368-78
Tomasevic, Gregor; Raghupathi, Ramesh; Scherbel, Uwe et al. (2010) Deletion of the p53 tumor suppressor gene improves neuromotor function but does not attenuate regional neuronal cell loss following experimental brain trauma in mice. J Neurosci Res 88:3414-23
Conte, Valeria; Raghupathi, Ramesh; Watson, Deborah J et al. (2008) TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice. Restor Neurol Neurosci 26:45-56
Schutz, Christian; Stover, John F; Thompson, Hilaire J et al. (2006) Acute, transient hemorrhagic hypotension does not aggravate structural damage or neurologic motor deficits but delays the long-term cognitive recovery following mild to moderate traumatic brain injury. Crit Care Med 34:492-501
Lifshitz, Jonathan; Janmey, Paul A; McIntosh, Tracy K (2006) Photon correlation spectroscopy of brain mitochondrial populations: application to traumatic brain injury. Exp Neurol 197:318-29
Boockvar, John A; Schouten, Joost; Royo, Nicolas et al. (2005) Experimental traumatic brain injury modulates the survival, migration, and terminal phenotype of transplanted epidermal growth factor receptor-activated neural stem cells. Neurosurgery 56:163-71; discussion 171
Thompson, Hilaire J; Hoover, Rachel C; Tkacs, Nancy C et al. (2005) Development of posttraumatic hyperthermia after traumatic brain injury in rats is associated with increased periventricular inflammation. J Cereb Blood Flow Metab 25:163-76
Zhang, Chen; Saatman, Kathryn E; Royo, Nicolas C et al. (2005) Delayed transplantation of human neurons following brain injury in rats: a long-term graft survival and behavior study. J Neurotrauma 22:1456-74
Lenzlinger, P M; Shimizu, S; Marklund, N et al. (2005) Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats. Neuroscience 134:1047-56
Conte, Valeria; Uryu, Kunihiro; Fujimoto, Scott et al. (2004) Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury. J Neurochem 90:758-64

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