Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM034921-11
Application #
2177652
Study Section
Biochemistry Study Section (BIO)
Project Start
1985-09-25
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

England, Jeneffer P; Hao, Yuxin; Bai, Lihui et al. (2018) Switching of the folding-energy landscape governs the allosteric activation of protein kinase A. Proc Natl Acad Sci U S A 115:E7478-E7485
Haushalter, Kristofer J; Casteel, Darren E; Raffeiner, Andrea et al. (2018) Phosphorylation of protein kinase A (PKA) regulatory subunit RI? by protein kinase G (PKG) primes PKA for catalytic activity in cells. J Biol Chem 293:4411-4421
P Barros, Emília; Malmstrom, Robert D; Nourbakhsh, Kimya et al. (2017) Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RI?. Biochemistry 56:1536-1545
Hao, Yuxin; Canavan, Clare; Taylor, Susan S et al. (2017) Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers. Sci Rep 7:10843
Ahuja, Lalima G; Kornev, Alexandr P; McClendon, Christopher L et al. (2017) Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proc Natl Acad Sci U S A 114:E931-E940
Burgers, Pepijn P; Bruystens, Jessica; Burnley, Rebecca J et al. (2016) Structure of smAKAP and its regulation by PKA-mediated phosphorylation. FEBS J 283:2132-48
Chávez-Vargas, Lydia; Adame-García, Sendi Rafael; Cervantes-Villagrana, Rodolfo Daniel et al. (2016) Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING. J Biol Chem 291:6182-99
Bruystens, Jessica Gh; Wu, Jian; Fortezzo, Audrey et al. (2016) Structure of a PKA RI? Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J Mol Biol 428:4890-4904
Akimoto, Madoka; McNicholl, Eric Tyler; Ramkissoon, Avinash et al. (2015) Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RI?. PLoS Biol 13:e1002305
Zhang, Ping; Ye, Feng; Bastidas, Adam C et al. (2015) An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure 23:1563-1572

Showing the most recent 10 out of 102 publications