Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM035252-10
Application #
3287686
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1994-01-01
Project End
1995-07-31
Budget Start
1994-01-01
Budget End
1994-07-31
Support Year
10
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Gunawardena, Shermali; Yang, Ge; Goldstein, Lawrence S B (2013) Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. Hum Mol Genet 22:3828-43
Reis, Gerald F; Yang, Ge; Szpankowski, Lukasz et al. (2012) Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. Mol Biol Cell 23:1700-14
Falzone, Tomás L; Gunawardena, Shermali; McCleary, David et al. (2010) Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies. Hum Mol Genet 19:4399-408
Abe, Namiko; Almenar-Queralt, Angels; Lillo, Concepcion et al. (2009) Sunday driver interacts with two distinct classes of axonal organelles. J Biol Chem 284:34628-39
Shah, Sameer B; Nolan, Rhiannon; Davis, Emily et al. (2009) Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiol Dis 36:11-25
Falzone, Tomás L; Stokin, Gorazd B; Lillo, Concepción et al. (2009) Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. J Neurosci 29:5758-67
Stokin, Gorazd B; Almenar-Queralt, Angels; Gunawardena, Shermali et al. (2008) Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Hum Mol Genet 17:3474-86
Xia, Chun-Hong; Roberts, Elizabeth A; Her, Lu-Shiun et al. (2003) Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol 161:55-66
Gunawardena, Shermali; Her, Lu-Shiun; Brusch, Richard G et al. (2003) Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron 40:25-40
Ji, Jun-Yuan; Haghnia, Marjan; Trusty, Cory et al. (2002) A genetic screen for suppressors and enhancers of the Drosophila cdk1-cyclin B identifies maternal factors that regulate microtubule and microfilament stability. Genetics 162:1179-95

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