Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM035394-12
Application #
2177884
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1985-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Wallen, Jamie R; Mallett, T Conn; Okuno, Takashi et al. (2015) Structural Analysis of Streptococcus pyogenes NADH Oxidase: Conformational Dynamics Involved in Formation of the C(4a)-Peroxyflavin Intermediate. Biochemistry 54:6815-29
Parsonage, Derek; Newton, Gerald L; Holder, Robert C et al. (2010) Characterization of the N-acetyl-ýý-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry 49:8398-414
Gaballa, Ahmed; Newton, Gerald L; Antelmann, Haike et al. (2010) Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. Proc Natl Acad Sci U S A 107:6482-6
Wallen, Jamie R; Mallett, T Conn; Boles, William et al. (2009) Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking. Biochemistry 48:9650-67
Newton, Gerald L; Rawat, Mamta; La Clair, James J et al. (2009) Bacillithiol is an antioxidant thiol produced in Bacilli. Nat Chem Biol 5:625-7
Rowan, Andrew S; Nicely, Nathan I; Cochrane, Nicola et al. (2009) Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase. Org Biomol Chem 7:4029-36
Paige, Carleitta; Reid, Sean D; Hanna, Philip C et al. (2008) The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis. J Bacteriol 190:6271-5
Colussi, Timothy; Parsonage, Derek; Boles, William et al. (2008) Structure of alpha-glycerophosphate oxidase from Streptococcus sp.: a template for the mitochondrial alpha-glycerophosphate dehydrogenase. Biochemistry 47:965-77
Wallen, Jamie R; Paige, Carleitta; Mallett, T Conn et al. (2008) Pyridine nucleotide complexes with Bacillus anthracis coenzyme A-disulfide reductase: a structural analysis of dual NAD(P)H specificity. Biochemistry 47:5182-93
Nicely, Nathan I; Parsonage, Derek; Paige, Carleitta et al. (2007) Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology. Biochemistry 46:3234-45

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