Abstract

The purpose of the research is the definition of the abnormalities of cellular immunity which occur after operative and accidential trauma and burns. We will study human subjects and an animal model in order to define relationships between circulating immunosuppressive polypeptide factor(s), diminished peripheral blood lymphocyte responsiveness to mitogenic stimulation and the presence of suppressor cells. We will also look for a correlation between the results of these in vitro tests or immunological impairment with in vivo manifestations of anergy, sepsis and mortality.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM035633-02
Application #
3288549
Study Section
(SSS)
Project Start
1985-02-01
Project End
1987-01-31
Budget Start
1986-02-01
Budget End
1987-01-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Hanschen, Marc; Tajima, Goro; O'Leary, Fionnuala et al. (2012) Phospho-flow cytometry based analysis of differences in T cell receptor signaling between regulatory T cells and CD4+ T cells. J Immunol Methods 376:1-12
Stoecklein, Veit M; Osuka, Akinori; Lederer, James A (2012) Trauma equals danger--damage control by the immune system. J Leukoc Biol 92:539-51
Osuka, Akinori; Hanschen, Marc; Stoecklein, Veit et al. (2012) A protective role for inflammasome activation following injury. Shock 37:47-55
O'Leary, Fionnuala M; Tajima, Goro; Delisle, Adam J et al. (2011) Injury-induced GR-1+ macrophage expansion and activation occurs independently of CD4 T-cell influence. Shock 36:162-9
Byrne, William L; Mills, Kingston H G; Lederer, James A et al. (2011) Targeting regulatory T cells in cancer. Cancer Res 71:6915-20
MacConmara, Malcolm P; Tajima, Goro; O'Leary, Fionnuala et al. (2011) Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury. J Leukoc Biol 89:137-47
Hanschen, Marc; Tajima, Goro; O'Leary, Fionnuala et al. (2011) Injury induces early activation of T-cell receptor signaling pathways in CD4+ regulatory T cells. Shock 35:252-7
Fujimi, Satoshi; Lapchak, Peter H; Zang, Yan et al. (2009) Murine dendritic cell antigen-presenting cell function is not altered by burn injury. J Leukoc Biol 85:862-70
Maung, Adrian A; Fujimi, Satoshi; MacConmara, Malcolm P et al. (2008) Injury enhances resistance to Escherichia coli infection by boosting innate immune system function. J Immunol 180:2450-8
Purcell, Elizabeth M; Dolan, Sinead M; Kriynovich, Sara et al. (2006) Burn injury induces an early activation response by lymph node CD4+ T cells. Shock 25:135-40

Showing the most recent 10 out of 52 publications