Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM035687-16
Application #
6430430
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Shapiro, Bert I
Project Start
1985-04-01
Project End
2005-12-31
Budget Start
2002-01-01
Budget End
2002-12-31
Support Year
16
Fiscal Year
2002
Total Cost
$287,560
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Biochemistry
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Braunger, Katharina; Pfeffer, Stefan; Shrimal, Shiteshu et al. (2018) Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Science 360:215-219
Mandon, Elisabet C; Butova, Cameron; Lachapelle, Amber et al. (2018) Conserved motifs on the cytoplasmic face of the protein translocation channel are critical for the transition between resting and active conformations. J Biol Chem 293:13662-13672
Tripathi, Arati; Mandon, Elisabet C; Gilmore, Reid et al. (2017) Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins. J Biol Chem 292:8007-8018
Mandon, Elisabet C; Trueman, Steven F; Gilmore, Reid (2013) Protein translocation across the rough endoplasmic reticulum. Cold Spring Harb Perspect Biol 5:
Trueman, Steven F; Mandon, Elisabet C; Gilmore, Reid (2012) A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function. J Cell Biol 199:907-18
Gilmore, Reid; Mandon, Elisabet C (2012) Understanding integration of ?-helical membrane proteins: the next steps. Trends Biochem Sci 37:303-8
Trueman, Steven F; Mandon, Elisabet C; Gilmore, Reid (2011) Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity. Mol Biol Cell 22:2983-93
Becker, Thomas; Bhushan, Shashi; Jarasch, Alexander et al. (2009) Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome. Science 326:1369-73
Mandon, Elisabet C; Trueman, Steven F; Gilmore, Reid (2009) Translocation of proteins through the Sec61 and SecYEG channels. Curr Opin Cell Biol 21:501-7
Jiang, Ying; Cheng, Zhiliang; Mandon, Elisabet C et al. (2008) An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation. J Cell Biol 180:1149-61

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