Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM035724-11
Application #
2178046
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1986-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
California Institute of Technology
Department
Chemistry
Type
Schools of Engineering
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Taylor, M J; Dervan, P B (1997) Kinetic analysis of sequence-specific alkylation of DNA by pyrimidine oligodeoxyribonucleotide-directed triple-helix formation. Bioconjug Chem 8:354-64
Hacia, J G; Wold, B J; Dervan, P B (1994) Phosphorothioate oligonucleotide-directed triple helix formation. Biochemistry 33:5367-9
Distefano, M D; Dervan, P B (1993) Energetics of cooperative binding of oligonucleotides with discrete dimerization domains to DNA by triple helix formation. Proc Natl Acad Sci U S A 90:1179-83
Singleton, S F; Dervan, P B (1993) Equilibrium association constants for oligonucleotide-directed triple helix formation at single DNA sites: linkage to cation valence and concentration. Biochemistry 32:13171-9
Singleton, S F; Dervan, P B (1992) Influence of pH on the equilibrium association constants for oligodeoxyribonucleotide-directed triple helix formation at single DNA sites. Biochemistry 31:10995-1003
Luebke, K J; Dervan, P B (1992) Nonenymatic ligation of double-helical DNA by alternate-strand triple helix formation. Nucleic Acids Res 20:3005-9
Maher 3rd, L J; Dervan, P B; Wold, B (1992) Analysis of promoter-specific repression by triple-helical DNA complexes in a eukaryotic cell-free transcription system. Biochemistry 31:70-81
Maher 3rd, L J; Dervan, P B; Wold, B J (1990) Kinetic analysis of oligodeoxyribonucleotide-directed triple-helix formation on DNA. Biochemistry 29:8820-6
Haner, R; Dervan, P B (1990) Single-strand DNA triple-helix formation. Biochemistry 29:9761-5
Plum, G E; Park, Y W; Singleton, S F et al. (1990) Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: a spectroscopic and calorimetric study. Proc Natl Acad Sci U S A 87:9436-40

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