Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM035866-11
Application #
2178104
Study Section
Biochemistry Study Section (BIO)
Project Start
1986-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical College of Georgia (MCG)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Augusta
State
GA
Country
United States
Zip Code
30912
Dynan, William S; Takeda, Yoshihiko; Li, Shuyi (2006) Modifying the function of DNA repair nanomachines for therapeutic benefit. Nanomedicine 2:74-81
Bladen, Catherine L; Udayakumar, Durga; Takeda, Yoshihiko et al. (2005) Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor. J Biol Chem 280:5205-10
Lee, Kyung-Jong; Jovanovic, Marko; Udayakumar, Durga et al. (2004) Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system. DNA Repair (Amst) 3:267-76
Udayakumar, Durga; Bladen, Catherine L; Hudson, Farlyn Z et al. (2003) Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation. J Biol Chem 278:41631-5
Li, Shuyi; Takeda, Yoshihiko; Wragg, Stephanie et al. (2003) Modification of the ionizing radiation response in living cells by an scFv against the DNA-dependent protein kinase. Nucleic Acids Res 31:5848-57
Lee, Kyung-Jong; Dong, Xingwen; Wang, Jingsong et al. (2002) Identification of human autoantibodies to the DNA ligase IV/XRCC4 complex and mapping of an autoimmune epitope to a potential regulatory region. J Immunol 169:3413-21
Mo, Xianming; Dynan, William S (2002) Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites. Mol Cell Biol 22:8088-99
Takeda, Y; Dynan, W S (2001) Autoantibodies against DNA double-strand break repair proteins. Front Biosci 6:D1412-22
Woodard, R L; Lee, K J; Huang, J et al. (2001) Distinct roles for Ku protein in transcriptional reinitiation and DNA repair. J Biol Chem 276:15423-33
Woodard, R L; Anderson, M G; Dynan, W S (1999) Nuclear extracts lacking DNA-dependent protein kinase are deficient in multiple round transcription. J Biol Chem 274:478-85

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