Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM036624-02S1
Application #
3290976
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1986-07-01
Project End
1991-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Wong, Kwok-Kin; Engelman, Jeffrey A; Cantley, Lewis C (2010) Targeting the PI3K signaling pathway in cancer. Curr Opin Genet Dev 20:87-90
Myers, Andrea P; Meyerhardt, Jeffrey A; Cantley, Lewis C (2009) Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy? Clin Cancer Res 15:6748-50
Engelman, Jeffrey A; Chen, Liang; Tan, Xiaohong et al. (2008) Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 14:1351-6
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Kapeller, R; Prasad, K V; Janssen, O et al. (1994) Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. J Biol Chem 269:1927-33
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Liscovitch, M; Chalifa, V; Pertile, P et al. (1994) Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. J Biol Chem 269:21403-6
Wong, K; Cantley, L C (1994) Cloning and characterization of a human phosphatidylinositol 4-kinase. J Biol Chem 269:28878-84
Prasad, K V; Janssen, O; Kapeller, R et al. (1993) Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. Proc Natl Acad Sci U S A 90:7366-70

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