Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM036780-11
Application #
2178515
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1986-04-04
Project End
1998-07-31
Budget Start
1996-07-01
Budget End
1998-07-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Pharmacy
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Chen, Ligong; Shu, Yan; Liang, Xiaomin et al. (2014) OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A 111:9983-8
Yee, Sook Wah; Chen, Ligong; Giacomini, Kathleen M (2012) The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet 44:359-60
Minematsu, Tsuyoshi; Giacomini, Kathleen M (2011) Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins. Mol Cancer Ther 10:531-9
Li, Shuanglian; Chen, Ying; Zhang, Shuzhong et al. (2011) Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice. Pharm Res 28:610-25
Choi, J H; Yee, S W; Ramirez, A H et al. (2011) A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Clin Pharmacol Ther 90:674-84
More, Swati S; Itsara, Melissa; Yang, Xiaodong et al. (2011) Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems. Clin Cancer Res 17:2339-49
Kido, Yasuto; Matsson, Pär; Giacomini, Kathleen M (2011) Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. J Med Chem 54:4548-58
Chen, Ligong; Takizawa, Miho; Chen, Eugene et al. (2010) Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function. J Pharmacol Exp Ther 335:42-50
Shima, James E; Komori, Takafumi; Taylor, Travis R et al. (2010) Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates. Am J Physiol Renal Physiol 299:F767-75
Chen, Ligong; Pawlikowski, Bradley; Schlessinger, Avner et al. (2010) Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin. Pharmacogenet Genomics 20:687-99

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