Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM036792-10
Application #
2178519
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1986-07-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Purdue University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Wang, Guangwei; Xu, Shiqing; Hu, Qian et al. (2013) Search for highly efficient, stereoselective, and practical synthesis of complex organic compounds of medicinal importance as exemplified by the synthesis of the C21-C37 fragment of amphotericin?B. Chemistry 19:12938-42
Xu, Shiqing; Lee, Ching-Tien; Wang, Guangwei et al. (2013) Widely applicable synthesis of enantiomerically pure tertiary alkyl-containing 1-alkanols by zirconium-catalyzed asymmetric carboalumination of alkenes and palladium- or copper-catalyzed cross-coupling. Chem Asian J 8:1829-35
Xu, Shiqing; Lee, Ching-Tien; Rao, Honghua et al. (2011) Highly(?98%) Stereo- and Regioselective Trisubstituted Alkene Synthesis of Wide Applicability via 1-Halo-1-alkyne Hydroboration-Tandem Negishi-Suzuki Coupling or Organoborate Migratory Insertion Protocol. Adv Synth Catal 353:2981-2987
Wang, Guangwei; Yin, Ning; Negishi, Ei-ichi (2011) Highly stereoselective total synthesis of fully hydroxy-protected mycolactones A and B and their stereoisomerization upon deprotection. Chemistry 17:4118-30
Negishi, Ei-Ichi; Wang, Guangwei; Rao, Honghua et al. (2010) Alkyne elementometalation-Pd-catalyzed cross-coupling. Toward synthesis of all conceivable types of acyclic alkenes in high yields, efficiently, selectively, economically, and safely: ""green"" way. J Org Chem 75:3151-82
Wang, Chao; Xu, Zhaoqing; Tobrman, Tomas et al. (2010) Arylethyne Bromoboration-Negishi Coupling Route to E- or Z-Aryl-Substituted Trisubstituted Alkenes of ?98% IsomericPurity. New Horizon in the Highly Selective Synthesis of Trisubstituted Alkenes. Adv Synth Catal 352:627-631
Negishi, Ei-Ichi; Tobrman, Tomas; Rao, Honghua et al. (2010) Highly(?98%) Selective Trisubstituted Alkene Synthesis of Wide Applicability via Fluoride-Promoted Pd-Catalyzed Cross-Coupling of Alkenylboranes. Isr J Chem 50:696-701
Wang, Guangwei; Negishi, Ei-Ichi (2009) AlCl3-Promoted Facile E-to-Z Isomerization Route to (Z)-2-Methyl-1-buten-1,4-ylidene Synthons for Highly Efficient and Selective (Z)-Isoprenoid Synthesis. European J Org Chem 2009:
Wang, Chao; Tobrman, Tomas; Xu, Zhaoqing et al. (2009) Highly regio- and stereoselective synthesis of (Z)-trisubstituted alkenes via propyne bromoboration and tandem Pd-catalyzed cross-coupling. Org Lett 11:4092-5
Wang, Guangwei; Huang, Zhihong; Negishi, Ei-Ichi (2008) Efficient and selective syntheses of (all-E)- and (6E,10Z)-2'-O-methylmyxalamides D via Pd-catalyzed alkenylation--carbonyl olefination synergy. Org Lett 10:3223-6

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