Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM036823-09
Application #
2178548
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1986-07-01
Project End
1997-11-30
Budget Start
1994-12-01
Budget End
1997-11-30
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Chicago
Department
Neurology
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Meijer, Laurent; Nelson, Deborah J; Riazanski, Vladimir et al. (2016) Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. J Innate Immun 8:330-49
Riazanski, Vladimir; Gabdoulkhakova, Aida G; Boynton, Lin S et al. (2015) TRPC6 channel translocation into phagosomal membrane augments phagosomal function. Proc Natl Acad Sci U S A 112:E6486-95
Domingue, Jada C; Ao, Mei; Sarathy, Jayashree et al. (2014) HEK-293 cells expressing the cystic fibrosis transmembrane conductance regulator (CFTR): a model for studying regulation of Cl- transport. Physiol Rep 2:
Farmer, Laurel M; Le, Brandy N; Nelson, Deborah J (2013) CLC-3 chloride channels moderate long-term potentiation at Schaffer collateral-CA1 synapses. J Physiol 591:1001-15
Riazanski, Vladimir; Deriy, Ludmila V; Shevchenko, Pavel D et al. (2011) Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus. Nat Neurosci 14:487-94
Deriy, Ludmila V; Gomez, Erwin A; Jacobson, David A et al. (2009) The granular chloride channel ClC-3 is permissive for insulin secretion. Cell Metab 10:316-23
Deriy, Ludmila V; Gomez, Erwin A; Zhang, Guangping et al. (2009) Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages. J Biol Chem 284:35926-38
Mitchell, Jennifer; Wang, Xueqing; Zhang, Guangping et al. (2008) An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function. Curr Biol 18:1600-5
Di, Anke; Brown, Mary E; Deriy, Ludmila V et al. (2006) CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat Cell Biol 8:933-44
Wang, Xue Qing; Deriy, Ludmila V; Foss, Sarah et al. (2006) CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons. Neuron 52:321-33

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