Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM036927-03
Application #
3291606
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1986-01-01
Project End
1989-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Yu, Olivia M; Benitez, Jorge A; Plouffe, Steven W et al. (2018) YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene 37:5492-5507
Dusaban, Stephanie S; Chun, Jerold; Rosen, Hugh et al. (2017) Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes. J Neuroinflammation 14:111
Yung, Bryan S; Brand, Cameron S; Xiang, Sunny Y et al. (2017) Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. J Mol Cell Cardiol 103:1-10
Yu, Olivia M; Miyamoto, Shigeki; Brown, Joan Heller (2016) Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation. Mol Cell Biol 36:39-49
Yu, Olivia M; Brown, Joan Heller (2015) G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation. Mol Pharmacol 88:171-80
Dusaban, Stephanie S; Kunkel, Maya T; Smrcka, Alan V et al. (2015) Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C?. J Biol Chem 290:26776-83
Dusaban, Stephanie S; Brown, Joan Heller (2015) PLC? mediated sustained signaling pathways. Adv Biol Regul 57:17-23
Sayyah, Jacqueline; Bartakova, Alena; Nogal, Nekeisha et al. (2014) The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. J Biol Chem 289:17689-98
Zhao, Xia; Ding, Eric Y; Yu, Olivia M et al. (2014) Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. J Mol Cell Cardiol 75:152-61
Dusaban, Stephanie S; Purcell, Nicole H; Rockenstein, Edward et al. (2013) Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. Proc Natl Acad Sci U S A 110:3609-14

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