Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM037065-02
Application #
3292014
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1986-07-01
Project End
1989-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Boston College
Department
Type
Schools of Arts and Sciences
DUNS #
045896339
City
Chestnut Hill
State
MA
Country
United States
Zip Code
02467
Gianolio, D A; McLaughlin, L W (2001) Tethered naphthalene diimide intercalators enhance DNA triplex stability. Bioorg Med Chem 9:2329-34
Wiederholt, K; Rajur, S B; McLaughlin, L W (1997) Oligonucleotides tethering Hoechst 33258 derivatives: effect of the conjugation site on duplex stabilization and fluorescence properties. Bioconjug Chem 8:119-26
O'Donnell, M J; Rajur, S B; McLaughlin, L W (1995) Synthesis and properties of a Hoechst-like minor-groove binding agent tethered to an oligodeoxynucleotide. Bioorg Med Chem 3:743-50
Fidanza, J A; Ozaki, H; McLaughlin, L W (1994) Functionalization of oligonucleotides by the incorporation of thio-specific reporter groups. Methods Mol Biol 26:121-43
Ozaki, H; McLaughlin, L W (1992) Fluorescence resonance energy transfer between specific-labeled sites on DNA. Nucleic Acids Symp Ser :67-8
Hall, K B; McLaughlin, L W (1992) Properties of pseudouridine N1 imino protons located in the major groove of an A-form RNA duplex. Nucleic Acids Res 20:1883-9
Ozaki, H; McLaughlin, L W (1992) The estimation of distances between specific backbone-labeled sites in DNA using fluorescence resonance energy transfer. Nucleic Acids Res 20:5205-14
Conway, N E; McLaughlin, L W (1991) The covalent attachment of multiple fluorophores to DNA containing phosphorothioate diesters results in highly sensitive detection of single-stranded DNA. Bioconjug Chem 2:452-7
Loontiens, F G; McLaughlin, L W; Diekmann, S et al. (1991) Binding of Hoechst 33258 and 4',6'-diamidino-2-phenylindole to self-complementary decadeoxynucleotides with modified exocyclic base substituents. Biochemistry 30:182-9
Hall, K B; McLaughlin, L W (1991) Properties of a U1/mRNA 5' splice site duplex containing pseudouridine as measured by thermodynamic and NMR methods. Biochemistry 30:1795-801

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