Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM038470-08A1
Application #
2179349
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1988-04-01
Project End
1999-11-30
Budget Start
1995-12-15
Budget End
1996-11-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Anatomy/Cell Biology
Type
Schools of Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
DeHart, Gregory W; Jones, Jonathan C R (2004) Myosin-mediated cytoskeleton contraction and Rho GTPases regulate laminin-5 matrix assembly. Cell Motil Cytoskeleton 57:107-17
deHart, Gregory W; Healy, Kevin E; Jones, Jonathan C R (2003) The role of alpha3beta1 integrin in determining the supramolecular organization of laminin-5 in the extracellular matrix of keratinocytes. Exp Cell Res 283:67-79
Gonzales, M; Weksler, B; Tsuruta, D et al. (2001) Structure and function of a vimentin-associated matrix adhesion in endothelial cells. Mol Biol Cell 12:85-100
Goldfinger, L E; Jiang, L; Hopkinson, S B et al. (2000) Spatial regulation and activity modulation of plasmin by high affinity binding to the G domain of the alpha 3 subunit of laminin-5. J Biol Chem 275:34887-93
Hopkinson, S B; Jones, J C (2000) The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome. Mol Biol Cell 11:277-86
Goldfinger, L E; Hopkinson, S B; deHart, G W et al. (1999) The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin. J Cell Sci 112 ( Pt 16):2615-29
Gonzales, M; Haan, K; Baker, S E et al. (1999) A cell signal pathway involving laminin-5, alpha3beta1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation. Mol Biol Cell 10:259-70
Chen, M; Marinkovich, M P; Jones, J C et al. (1999) NC1 domain of type VII collagen binds to the beta3 chain of laminin 5 via a unique subdomain within the fibronectin-like repeats. J Invest Dermatol 112:177-83
Hopkinson, S B; Findlay, K; deHart, G W et al. (1998) Interaction of BP180 (type XVII collagen) and alpha6 integrin is necessary for stabilization of hemidesmosome structure. J Invest Dermatol 111:1015-22
El-Ghannam, A; Starr, L; Jones, J (1998) Laminin-5 coating enhances epithelial cell attachment, spreading, and hemidesmosome assembly on Ti-6A1-4V implant material in vitro. J Biomed Mater Res 41:30-40

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