Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM039066-09
Application #
2179662
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1988-02-01
Project End
1998-03-31
Budget Start
1996-07-01
Budget End
1998-03-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cornell University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Shin, Myungjoo; van Leeuwen, Jolanda; Boone, Charles et al. (2018) Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables. Mol Biol Cell 29:923-936
Lwin, Kyaw Myo; Li, Donghao; Bretscher, Anthony (2016) Kinesin-related Smy1 enhances the Rab-dependent association of myosin-V with secretory cargo. Mol Biol Cell 27:2450-62
Donovan, Kirk W; Bretscher, Anthony (2015) Head-to-tail regulation is critical for the in vivo function of myosin V. J Cell Biol 209:359-65
Donovan, Kirk W; Bretscher, Anthony (2015) Tracking individual secretory vesicles during exocytosis reveals an ordered and regulated process. J Cell Biol 210:181-9
Xu, Li; Bretscher, Anthony (2014) Rapid glucose depletion immobilizes active myosin V on stabilized actin cables. Curr Biol 24:2471-9
Wayt, Jessica; Bretscher, Anthony (2014) Cordon Bleu serves as a platform at the basal region of microvilli, where it regulates microvillar length through its WH2 domains. Mol Biol Cell 25:2817-27
Viswanatha, Raghuvir; Bretscher, Anthony; Garbett, Damien (2014) Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells. Biochem Soc Trans 42:189-94
Bretscher, Anthony (2013) Deconstructing formin-dependent actin cable assembly. Proc Natl Acad Sci U S A 110:18744-5
Chernyakov, Irina; Santiago-Tirado, Felipe; Bretscher, Anthony (2013) Active segregation of yeast mitochondria by Myo2 is essential and mediated by Mmr1 and Ypt11. Curr Biol 23:1818-24
Liu, Wenyu; Santiago-Tirado, Felipe H; Bretscher, Anthony (2012) Yeast formin Bni1p has multiple localization regions that function in polarized growth and spindle orientation. Mol Biol Cell 23:412-22

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