Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM039341-09
Application #
2179762
Study Section
Genetics Study Section (GEN)
Project Start
1988-02-01
Project End
1997-06-30
Budget Start
1996-02-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Whitehead Institute for Biomedical Research
Department
Type
DUNS #
076580745
City
Cambridge
State
MA
Country
United States
Zip Code
02142
Hara, Masatoshi; Lourido, Sebastian; Petrova, Boryana et al. (2018) Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition. Elife 7:
Hara, Masatoshi; Petrova, Boryana; Orr-Weaver, Terry L (2017) Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation. Elife 6:
Eichhorn, Stephen W; Subtelny, Alexander O; Kronja, Iva et al. (2016) mRNA poly(A)-tail changes specified by deadenylation broadly reshape translation in Drosophila oocytes and early embryos. Elife 5:
Kronja, Iva; Yuan, Bingbing; Eichhorn, Stephen W et al. (2014) Widespread changes in the posttranscriptional landscape at the Drosophila oocyte-to-embryo transition. Cell Rep 7:1495-1508
Kronja, Iva; Whitfield, Zachary J; Yuan, Bingbing et al. (2014) Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition. Proc Natl Acad Sci U S A 111:16023-8
Whitfield, Zachary J; Chisholm, Jennifer; Hawley, R Scott et al. (2013) A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony. PLoS Biol 11:e1001648
Unhavaithaya, Yingdee; Orr-Weaver, Terry L (2013) Centromere proteins CENP-C and CAL1 functionally interact in meiosis for centromere clustering, pairing, and chromosome segregation. Proc Natl Acad Sci U S A 110:19878-83
Unhavaithaya, Yingdee; Park, Eugenia A; Royzman, Irena et al. (2013) Drosophila embryonic cell-cycle mutants. G3 (Bethesda) 3:1875-80
Kronja, Iva; Orr-Weaver, Terry L (2011) Translational regulation of the cell cycle: when, where, how and why? Philos Trans R Soc Lond B Biol Sci 366:3638-52
Von Stetina, Jessica R; Orr-Weaver, Terry L (2011) Developmental control of oocyte maturation and egg activation in metazoan models. Cold Spring Harb Perspect Biol 3:a005553

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