Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM039799-09
Application #
2180045
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1988-04-01
Project End
1997-06-30
Budget Start
1996-04-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Yabuki, Munehisa; Cummings, W Jason; Leppard, John B et al. (2012) Antibody discovery ex vivo accelerated by the LacO/LacI regulatory network. PLoS One 7:e36032
Yabuki, Munehisa; Ordinario, Ellen C; Cummings, W Jason et al. (2009) E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification. J Immunol 182:408-15
Ordinario, Ellen C; Yabuki, Munehisa; Larson, Ryan P et al. (2009) Temporal regulation of Ig gene diversification revealed by single-cell imaging. J Immunol 183:4545-53
Vallur, Aarthy C; Maizels, Nancy (2008) Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions. Proc Natl Acad Sci U S A 105:16508-12
Vallur, A C; Yabuki, M; Larson, E D et al. (2007) AID in antibody perfection. Cell Mol Life Sci 64:555-65
Maizels, Nancy (2006) Dynamic roles for G4 DNA in the biology of eukaryotic cells. Nat Struct Mol Biol 13:1055-9
Maizels, Nancy (2005) Immunoglobulin gene diversification. Annu Rev Genet 39:23-46
Larson, Erik D; Duquette, Michelle L; Cummings, W Jason et al. (2005) MutSalpha binds to and promotes synapsis of transcriptionally activated immunoglobulin switch regions. Curr Biol 15:470-4
Larson, Erik D; Cummings, W Jason; Bednarski, David W et al. (2005) MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification. Mol Cell 20:367-75
Yabuki, Munehisa; Fujii, Monica M; Maizels, Nancy (2005) The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions. Nat Immunol 6:730-6

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