Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM040000-05S1
Application #
2180139
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1988-06-01
Project End
1997-06-30
Budget Start
1994-07-01
Budget End
1995-06-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Harvard University
Department
Other Basic Sciences
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Quiñones, Jason L; Thapar, Upasna; Yu, Kefei et al. (2015) Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase ? in vivo. Proc Natl Acad Sci U S A 112:8602-7
Madlener, Sibylle; Ströbel, Thomas; Vose, Sarah et al. (2013) Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance. Proc Natl Acad Sci U S A 110:17844-9
Fung, Hua; Demple, Bruce (2011) Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin. J Biol Chem 286:4968-77
Liu, Pingfang; Demple, Bruce (2010) DNA repair in mammalian mitochondria: Much more than we thought? Environ Mol Mutagen 51:417-26
Auerbach, Paul A; Demple, Bruce (2010) Roles of Rev1, Pol zeta, Pol32 and Pol eta in the bypass of chromosomal abasic sites in Saccharomyces cerevisiae. Mutagenesis 25:63-9
Son, Mi-Young; Jun, Hyun-Ik; Lee, Kwang-Geun et al. (2009) Biochemical evaluation of genotoxic biomarkers for 2-deoxyribonolactone-mediated cross-link formation with histones. J Toxicol Environ Health A 72:1311-7
Zheng, Li; Zhou, Mian; Guo, Zhigang et al. (2008) Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. Mol Cell 32:325-36
Liu, Pingfang; Qian, Limin; Sung, Jung-Suk et al. (2008) Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol 28:4975-87
Gellon, Lionel; Carson, Dena R; Carson, Jonathan P et al. (2008) Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair. DNA Repair (Amst) 7:187-98
Fung, Hua; Liu, Pingfang; Demple, Bruce (2007) ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis. Mol Cell Biol 27:8834-47

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