Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM040403-11
Application #
2900689
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Program Officer
Anderson, James J
Project Start
1988-07-01
Project End
2002-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
11
Fiscal Year
1999
Total Cost
Indirect Cost
Name
West Virginia University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
Wang, L; Wilson, S; Elliott, T (1999) A mutant HemA protein with positive charge close to the N terminus is stabilized against heme-regulated proteolysis in Salmonella typhimurium. J Bacteriol 181:6033-41
Cunning, C; Elliott, T (1999) RpoS synthesis is growth rate regulated in Salmonella typhimurium, but its turnover is not dependent on acetyl phosphate synthesis or PTS function. J Bacteriol 181:4853-62
Wang, L; Elliott, M; Elliott, T (1999) Conditional stability of the HemA protein (glutamyl-tRNA reductase) regulates heme biosynthesis in Salmonella typhimurium. J Bacteriol 181:1211-9
Majdalani, N; Cunning, C; Sledjeski, D et al. (1998) DsrA RNA regulates translation of RpoS message by an anti-antisense mechanism, independent of its action as an antisilencer of transcription. Proc Natl Acad Sci U S A 95:12462-7
Brown, L; Elliott, T (1997) Mutations that increase expression of the rpoS gene and decrease its dependence on hfq function in Salmonella typhimurium. J Bacteriol 179:656-62
Wang, L Y; Brown, L; Elliott, M et al. (1997) Regulation of heme biosynthesis in Salmonella typhimurium: activity of glutamyl-tRNA reductase (HemA) is greatly elevated during heme limitation by a mechanism which increases abundance of the protein. J Bacteriol 179:2907-14
Choi, P; Wang, L; Archer, C D et al. (1996) Transcription of the glutamyl-tRNA reductase (hemA) gene in Salmonella typhimurium and Escherichia coli: role of the hemA P1 promoter and the arcA gene product. J Bacteriol 178:638-46
Brown, L; Elliott, T (1996) Efficient translation of the RpoS sigma factor in Salmonella typhimurium requires host factor I, an RNA-binding protein encoded by the hfq gene. J Bacteriol 178:3763-70
Michalakis, Y; Slatkin, M (1996) Interaction of selection and recombination in the fixation of negative-epistatic genes. Genet Res 67:257-69
Archer, C D; Jin, J; Elliott, T (1996) Stabilization of a HemA-LacZ hybrid protein against proteolysis during carbon starvation in atp mutants of Salmonella typhimurium. J Bacteriol 178:2462-4

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