Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM040711-09
Application #
2180537
Study Section
Pathology A Study Section (PTHA)
Project Start
1989-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Cheng, Lamei; Sage, E Helene; Yan, Qi (2013) SPARC fusion protein induces cellular adhesive signaling. PLoS One 8:e53202
Millecamps, Magali; Tajerian, Maral; Naso, Lina et al. (2012) Lumbar intervertebral disc degeneration associated with axial and radiating low back pain in ageing SPARC-null mice. Pain 153:1167-79
Kucukdereli, Hakan; Allen, Nicola J; Lee, Anthony T et al. (2011) Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. Proc Natl Acad Sci U S A 108:E440-9
Nie, Jing; Bradshaw, Amy D; Delany, Anne M et al. (2011) Inactivation of SPARC enhances high-fat diet-induced obesity in mice. Connect Tissue Res 52:99-108
Workman, Gail; Sage, E Helene (2011) Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1. J Cell Biochem 112:1003-8
Millecamps, Magali; Tajerian, Maral; Sage, E Helene et al. (2011) Behavioral signs of chronic back pain in the SPARC-null mouse. Spine (Phila Pa 1976) 36:95-102
Weaver, Matt; Workman, Gail; Schultz, Chad R et al. (2011) Proteolysis of the matricellular protein hevin by matrix metalloproteinase-3 produces a SPARC-like fragment (SLF) associated with neovasculature in a murine glioma model. J Cell Biochem 112:3093-102
Weaver, Matt S; Workman, Gail; Cardo-Vila, Marina et al. (2010) Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4. J Biol Chem 285:5868-77
Arnold, Shanna A; Rivera, Lee B; Miller, Andrew F et al. (2010) Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma. Dis Model Mech 3:57-72
Schellings, Mark W M; Vanhoutte, Davy; Swinnen, Melissa et al. (2009) Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction. J Exp Med 206:113-23

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