Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM040731-09
Application #
2180553
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1988-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309
Parkinson, John S; Hazelbauer, Gerald L; Falke, Joseph J (2015) Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update. Trends Microbiol 23:257-66
Briegel, Ariane; Wong, Margaret L; Hodges, Heather L et al. (2014) New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography. Biochemistry 53:1575-85
Briegel, Ariane; Wong, Margaret L; Hodges, Heather L et al. (2014) Correction to new insights into bacterial chemoreceptor array structure and assembly from electron cryotomography. Biochemistry 53:6624
Falke, Joseph J; Piasta, Kene N (2014) Architecture and signal transduction mechanism of the bacterial chemosensory array: progress, controversies, and challenges. Curr Opin Struct Biol 29:85-94
Piasta, Kene N; Falke, Joseph J (2014) Increasing and decreasing the ultrastability of bacterial chemotaxis core signaling complexes by modifying protein-protein contacts. Biochemistry 53:5592-600
Falke, Joseph J (2014) Piston versus scissors: chemotaxis receptors versus sensor His-kinase receptors in two-component signaling pathways. Structure 22:1219-1220
Li, Xiaoxiao; Fleetwood, Aaron D; Bayas, Camille et al. (2013) The 3.2 Å resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays. Biochemistry 52:3852-65
Natale, Andrew M; Duplantis, Jane L; Piasta, Kene N et al. (2013) Structure, function, and on-off switching of a core unit contact between CheA kinase and CheW adaptor protein in the bacterial chemosensory array: A disulfide mapping and mutagenesis study. Biochemistry 52:7753-65
Piasta, Kene N; Ulliman, Caleb J; Slivka, Peter F et al. (2013) Defining a key receptor-CheA kinase contact and elucidating its function in the membrane-bound bacterial chemosensory array: a disulfide mapping and TAM-IDS Study. Biochemistry 52:3866-80
Slivka, Peter F; Falke, Joseph J (2012) Isolated bacterial chemosensory array possesses quasi- and ultrastable components: functional links between array stability, cooperativity, and order. Biochemistry 51:10218-28

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