Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM040894-12
Application #
2180609
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1988-07-01
Project End
1998-03-31
Budget Start
1996-07-01
Budget End
1998-03-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Guo, Hong; Tullius, Thomas D (2003) Gapped DNA is anisotropically bent. Proc Natl Acad Sci U S A 100:3743-7
Chen, Bingzi; Jamieson, Elizabeth R; Tullius, Thomas D (2002) A general synthesis of specifically deuterated nucleotides for studies of DNA and RNA. Bioorg Med Chem Lett 12:3093-6
Balasubramanian, B; Pogozelski, W K; Tullius, T D (1998) DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone. Proc Natl Acad Sci U S A 95:9738-43
Shadle, S E; Allen, D F; Guo, H et al. (1997) Quantitative analysis of electrophoresis data: novel curve fitting methodology and its application to the determination of a protein-DNA binding constant. Nucleic Acids Res 25:850-60
Ganunis, R M; Guo, H; Tullius, T D (1996) Effect of the crystallizing agent 2-methyl-2,4-pentanediol on the structure of adenine tract DNA in solution. Biochemistry 35:13729-32
Price, M A; Tullius, T D (1993) How the structure of an adenine tract depends on sequence context: a new model for the structure of TnAn DNA sequences. Biochemistry 32:127-36
Kimball, A S; Lee, J; Jayaram, M et al. (1993) Sequence-specific cleavage of DNA via nucleophilic attack of hydrogen peroxide, assisted by Flp recombinase. Biochemistry 32:4698-701
Price, M A; Tullius, T D (1992) Using hydroxyl radical to probe DNA structure. Methods Enzymol 212:194-219
Churchill, M E; Hayes, J J; Tullius, T D (1990) Detection of drug binding to DNA by hydroxyl radical footprinting. Relationship of distamycin binding sites to DNA structure and positioned nucleosomes on 5S RNA genes of Xenopus. Biochemistry 29:6043-50
Guo, Q; Lu, M; Churchill, M E et al. (1990) Asymmetric structure of a three-arm DNA junction. Biochemistry 29:10927-34

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