Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM041302-02S1
Application #
3299418
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1990-09-01
Project End
1993-11-30
Budget Start
1990-09-01
Budget End
1990-11-30
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Luo, Guangzuo; Costanzo, Michael; Boone, Charles et al. (2011) Nutrients and the Pkh1/2 and Pkc1 protein kinases control mRNA decay and P-body assembly in yeast. J Biol Chem 286:8759-70
Dickson, Robert C (2010) Roles for sphingolipids in Saccharomyces cerevisiae. Adv Exp Med Biol 688:217-31
Luo, Guangzuo; Gruhler, Albrecht; Liu, Ying et al. (2008) The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover. J Biol Chem 283:10433-44
Brace, Jennifer L; Lester, Robert L; Dickson, Robert C et al. (2007) SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae. Genetics 175:65-76
Linn, Stephen C; Andras, Lindsay M; Kim, Hee-Sook et al. (2006) Functional characterization of the promoter for the mouse SPTLC2 gene, which encodes subunit 2 of serine palmitoyltransferase. FEBS Lett 580:6217-23
Valachovic, Martin; Bareither, Bart M; Shah Alam Bhuiyan, M et al. (2006) Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles. Genetics 173:1893-908
Dickson, Robert C; Sumanasekera, Chiranthani; Lester, Robert L (2006) Functions and metabolism of sphingolipids in Saccharomyces cerevisiae. Prog Lipid Res 45:447-65
Liu, Ke; Zhang, Xiping; Lester, Robert L et al. (2005) The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9. J Biol Chem 280:22679-87
Zhang, Xiping; Lester, Robert L; Dickson, Robert C (2004) Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p. J Biol Chem 279:22030-8
Chung, Ji-Hyun; Lester, Robert L; Dickson, Robert C (2003) Sphingolipid requirement for generation of a functional v1 component of the vacuolar ATPase. J Biol Chem 278:28872-81

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