Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM041788-08
Application #
2181053
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1989-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Ohio State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Sekar, K; Yogavel, M; Gayathri, D et al. (2006) Atomic resolution structure of the double mutant (K53,56M) of bovine pancreatic phospholipase A2. Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1-5
Sekar, K; Rajakannan, V; Gayathri, D et al. (2005) Atomic resolution (0.97 A) structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2. Acta Crystallogr Sect F Struct Biol Cryst Commun 61:3-7
Yu, Bao-Zhu; Apitz-Castro, Rafael; Tsai, Ming-Daw et al. (2003) Interaction of monodisperse anionic amphiphiles with the i-face of secreted phospholipase A2. Biochemistry 42:6293-301
Sekar, K; Vaijayanthi Mala, S; Yogavel, M et al. (2003) Crystal structures of the free and anisic acid bound triple mutant of phospholipase A2. J Mol Biol 333:367-76
Poi, Ming Jye; Tomaszewski, John W; Yuan, Chunhua et al. (2003) A low-barrier hydrogen bond between histidine of secreted phospholipase A2 and a transition state analog inhibitor. J Mol Biol 329:997-1009
Rajakannan, V; Yogavel, M; Poi, Ming-Jye et al. (2002) Observation of additional calcium ion in the crystal structure of the triple mutant K56,120,121M of bovine pancreatic phospholipase A2. J Mol Biol 324:755-62
Berg, O G; Gelb, M H; Tsai, M D et al. (2001) Interfacial enzymology: the secreted phospholipase A(2)-paradigm. Chem Rev 101:2613-54
Yu, B Z; Poi, M J; Ramagopal, U A et al. (2000) Structural basis of the anionic interface preference and kcat* activation of pancreatic phospholipase A2. Biochemistry 39:12312-23
Sekar, K; Biswas, R; Li, Y et al. (1999) Structures of the catalytic site mutants D99A and H48Q and the calcium-loop mutant D49E of phospholipase A2. Acta Crystallogr D Biol Crystallogr 55:443-7
Yuan, C; Tsai, M (1999) Pancreatic phospholipase A(2): new views on old issues. Biochim Biophys Acta 1441:215-22

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