Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM042033-08
Application #
2181198
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1989-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wesleyan University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Middletown
State
CT
Country
United States
Zip Code
06459
Auclair, Sarah M; Oliver, Donald B; Mukerji, Ishita (2013) Defining the solution state dimer structure of Escherichia coli SecA using Forster resonance energy transfer. Biochemistry 52:2388-401
Das, Sanchaita; Grady, Lorry M; Michtavy, Jennifer et al. (2012) The variable subdomain of Escherichia coli SecA functions to regulate SecA ATPase activity and ADP release. J Bacteriol 194:2205-13
Grady, Lorry M; Michtavy, Jennifer; Oliver, Donald B (2012) Characterization of the Escherichia coli SecA signal peptide-binding site. J Bacteriol 194:307-16
Auclair, Sarah M; Moses, Julia P; Musial-Siwek, Monika et al. (2010) Mapping of the signal peptide-binding domain of Escherichia coli SecA using Förster resonance energy transfer. Biochemistry 49:782-92
Das, Sanchaita; Stivison, Elizabeth; Folta-Stogniew, Ewa et al. (2008) Reexamination of the role of the amino terminus of SecA in promoting its dimerization and functional state. J Bacteriol 190:7302-7
Jilaveanu, Lucia B; Oliver, Donald B (2007) In vivo membrane topology of Escherichia coli SecA ATPase reveals extensive periplasmic exposure of multiple functionally important domains clustering on one face of SecA. J Biol Chem 282:4661-8
Jilaveanu, Lucia B; Oliver, Donald (2006) SecA dimer cross-linked at its subunit interface is functional for protein translocation. J Bacteriol 188:335-8
Jilaveanu, Lucia B; Zito, Christopher R; Oliver, Donald (2005) Dimeric SecA is essential for protein translocation. Proc Natl Acad Sci U S A 102:7511-6
Zito, Christopher R; Antony, Edwin; Hunt, John F et al. (2005) Role of a conserved glutamate residue in the Escherichia coli SecA ATPase mechanism. J Biol Chem 280:14611-9
Zito, Christopher R; Oliver, Donald (2003) Two-stage binding of SecA to the bacterial translocon regulates ribosome-translocon interaction. J Biol Chem 278:40640-6

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