Abstract

This application will investigate the chromatin structure of sites of HIV-1 integration.
Specific aims i nclude: 1. Refine the linear map of HIV-1 chromatin, obtain three dimensional structure of HIV-1 chromatin particle. 2. Identify sites that are nucleosome-free in a number of HIV-1 strains. 3. Identify chromatin and chromosomal sites of integration of HIV. 4. Examine HIV-1 RNA structure including the RRE region of HIV.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM042342-11
Application #
6018772
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1989-04-01
Project End
2001-08-31
Budget Start
1999-09-01
Budget End
2001-08-31
Support Year
11
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599