Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM042762-07
Application #
2181650
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1989-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Arizona
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Marklund, Erik G; Zhang, Yichen; Basha, Eman et al. (2018) Structural and functional aspects of the interaction partners of the small heat-shock protein in Synechocystis. Cell Stress Chaperones 23:723-732
Santhanagopalan, Indu; Degiacomi, Matteo T; Shepherd, Dale A et al. (2018) It takes a dimer to tango: Oligomeric small heat shock proteins dissociate to capture substrate. J Biol Chem 293:19511-19521
Haslbeck, Martin; Vierling, Elizabeth (2015) A first line of stress defense: small heat shock proteins and their function in protein homeostasis. J Mol Biol 427:1537-48
Patel, Sunita; Vierling, Elizabeth; Tama, Florence (2014) Replica exchange molecular dynamics simulations provide insight into substrate recognition by small heat shock proteins. Biophys J 106:2644-55
Basha, Eman; Jones, Christopher; Blackwell, Anne E et al. (2013) An unusual dimeric small heat shock protein provides insight into the mechanism of this class of chaperones. J Mol Biol 425:1683-96
Basha, Eman; O'Neill, Heather; Vierling, Elizabeth (2012) Small heat shock proteins and ?-crystallins: dynamic proteins with flexible functions. Trends Biochem Sci 37:106-17
Benesch, Justin L P; Aquilina, J Andrew; Baldwin, Andrew J et al. (2010) The quaternary organization and dynamics of the molecular chaperone HSP26 are thermally regulated. Chem Biol 17:1008-17
Basha, Eman; Jones, Christopher; Wysocki, Vicki et al. (2010) Mechanistic differences between two conserved classes of small heat shock proteins found in the plant cytosol. J Biol Chem 285:11489-97
Jaya, Nomalie; Garcia, Victor; Vierling, Elizabeth (2009) Substrate binding site flexibility of the small heat shock protein molecular chaperones. Proc Natl Acad Sci U S A 106:15604-9
Painter, Alexander J; Jaya, Nomalie; Basha, Eman et al. (2008) Real-time monitoring of protein complexes reveals their quaternary organization and dynamics. Chem Biol 15:246-53

Showing the most recent 10 out of 28 publications