Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM043129-09
Application #
6013592
Study Section
Project Start
1998-08-01
Project End
2000-11-30
Budget Start
1998-08-01
Budget End
1998-11-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Rai, Priyamvada; Wemmer, David E; Linn, Stuart (2005) Preferential binding and structural distortion by Fe2+ at RGGG-containing DNA sequences correlates with enhanced oxidative cleavage at such sequences. Nucleic Acids Res 33:497-510
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Hawkins, Cheryl A; Baird, Eldon E; Dervan, Peter B et al. (2002) Analysis of hairpin polyamide complexes having DNA binding sites in close proximity. J Am Chem Soc 124:12689-96
Supekova, Lubica; Pezacki, John Paul; Su, Andrew I et al. (2002) Genomic effects of polyamide/DNA interactions on mRNA expression. Chem Biol 9:821-7
Zhang, Q; Harada, K; Cho, H S et al. (2001) Structural characterization of the complex of the Rev response element RNA with a selected peptide. Chem Biol 8:511-20
Rai, P; Cole, T D; Wemmer, D E et al. (2001) Localization of Fe(2+) at an RTGR sequence within a DNA duplex explains preferential cleavage by Fe(2+) and H2O2. J Mol Biol 312:1089-101
Rentzeperis, D; Marky, L A; Dwyer, T J et al. (1995) Interaction of minor groove ligands to an AAATT/AATTT site: correlation of thermodynamic characterization and solution structure. Biochemistry 34:2937-45
Geierstanger, B H; Mrksich, M; Dervan, P B et al. (1994) Design of a G.C-specific DNA minor groove-binding peptide. Science 266:646-50
Geierstanger, B H; Jacobsen, J P; Mrksich, M et al. (1994) Structural and dynamic characterization of the heterodimeric and homodimeric complexes of distamycin and 1-methylimidazole-2-carboxamide-netropsin bound to the minor groove of DNA. Biochemistry 33:3055-62
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