Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM043369-06
Application #
2181984
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1991-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brandeis University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454
Tetone, Larry E; Friedman, Larry J; Osborne, Melisa L et al. (2017) Dynamics of GreB-RNA polymerase interaction allow a proofreading accessory protein to patrol for transcription complexes needing rescue. Proc Natl Acad Sci U S A 114:E1081-E1090
Paramanathan, Thayaparan; Reeves, Daniel; Friedman, Larry J et al. (2014) A general mechanism for competitor-induced dissociation of molecular complexes. Nat Commun 5:5207
Anderson, Eric G; Hoskins, Aaron A (2014) Single molecule approaches for studying spliceosome assembly and catalysis. Methods Mol Biol 1126:217-41
Smith, Benjamin A; Daugherty-Clarke, Karen; Goode, Bruce L et al. (2013) Pathway of actin filament branch formation by Arp2/3 complex revealed by single-molecule imaging. Proc Natl Acad Sci U S A 110:1285-90
Shcherbakova, Inna; Hoskins, Aaron A; Friedman, Larry J et al. (2013) Alternative spliceosome assembly pathways revealed by single-molecule fluorescence microscopy. Cell Rep 5:151-65
Smith, Benjamin A; Padrick, Shae B; Doolittle, Lynda K et al. (2013) Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation. Elife 2:e01008
Crawford, Daniel J; Hoskins, Aaron A; Friedman, Larry J et al. (2013) Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5' splice site and branch site. Proc Natl Acad Sci U S A 110:6783-8
Breitsprecher, Dennis; Jaiswal, Richa; Bombardier, Jeffrey P et al. (2012) Rocket launcher mechanism of collaborative actin assembly defined by single-molecule imaging. Science 336:1164-8
Garcia, Hernan G; Sanchez, Alvaro; Boedicker, James Q et al. (2012) Operator sequence alters gene expression independently of transcription factor occupancy in bacteria. Cell Rep 2:150-61
Friedman, Larry J; Gelles, Jeff (2012) Mechanism of transcription initiation at an activator-dependent promoter defined by single-molecule observation. Cell 148:679-89

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