Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM043601-06A2
Application #
2182111
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1989-12-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
de Poot, Stefanie A H; Tian, Geng; Finley, Daniel (2017) Meddling with Fate: The Proteasomal Deubiquitinating Enzymes. J Mol Biol 429:3525-3545
Peng, Hong; Yang, Jiao; Li, Guangyi et al. (2017) Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress. Cell Res 27:657-674
Boselli, Monica; Lee, Byung-Hoon; Robert, Jessica et al. (2017) An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem 292:19209-19225
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Li, Frances; Tian, Geng; Langager, Deanna et al. (2017) Nucleotide-dependent switch in proteasome assembly mediated by the Nas6 chaperone. Proc Natl Acad Sci U S A 114:1548-1553
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Choi, Won Hoon; de Poot, Stefanie A H; Lee, Jung Hoon et al. (2016) Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation. Nat Commun 7:10963
Finley, Daniel; Chen, Xiang; Walters, Kylie J (2016) Gates, Channels, and Switches: Elements of the Proteasome Machine. Trends Biochem Sci 41:77-93
Luan, Bai; Huang, Xiuliang; Wu, Jianping et al. (2016) Structure of an endogenous yeast 26S proteasome reveals two major conformational states. Proc Natl Acad Sci U S A 113:2642-7

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