Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM044025-07
Application #
2182331
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1990-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Berry, Katherine E; Hochschild, Ann (2018) A bacterial three-hybrid assay detects Escherichia coli Hfq-sRNA interactions in vivo. Nucleic Acids Res 46:e12
Wang Erickson, Anna F; Deighan, Padraig; Garcia, Cinthia P et al. (2017) An Amino Acid Substitution in RNA Polymerase That Inhibits the Utilization of an Alternative Sigma Factor. J Bacteriol 199:
Wang Erickson, Anna F; Deighan, Padraig; Chen, Shanshan et al. (2017) A novel RNA polymerase-binding protein that interacts with a sigma-factor docking site. Mol Microbiol 105:652-662
Wells, Christopher D; Deighan, Padraig; Brigham, MacKenzie et al. (2016) Nascent RNA length dictates opposing effects of NusA on antitermination. Nucleic Acids Res 44:5378-89
Harden, Timothy T; Wells, Christopher D; Friedman, Larry J et al. (2016) Bacterial RNA polymerase can retain ?70 throughout transcription. Proc Natl Acad Sci U S A 113:602-7
Goldman, Seth R; Nair, Nikhil U; Wells, Christopher D et al. (2015) The primary ? factor in Escherichia coli can access the transcription elongation complex from solution in vivo. Elife 4:
Hochschild, Ann (2015) Mastering Transcription: Multiplexed Analysis of Transcription Start Site Sequences. Mol Cell 60:829-31
Bikard, David; Jiang, Wenyan; Samai, Poulami et al. (2013) Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res 41:7429-37
Montero-Diez, Cristina; Deighan, Padraig; Osmundson, Joseph et al. (2013) Phage-encoded inhibitor of Staphylococcus aureus transcription exerts context-dependent effects on promoter function in a modified Escherichia coli-based transcription system. J Bacteriol 195:3621-8
Osmundson, Joseph; Montero-Diez, Cristina; Westblade, Lars F et al. (2012) Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein. Cell 151:1005-16

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