Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM044500-07
Application #
2182541
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1990-08-15
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Leloir Institute
Department
Type
DUNS #
City
State
Country
Argentina
Zip Code
Olson, Linda J; Orsi, Ramiro; Alculumbre, Solana G et al. (2013) Structure of the lectin mannose 6-phosphate receptor homology (MRH) domain of glucosidase II, an enzyme that regulates glycoprotein folding quality control in the endoplasmic reticulum. J Biol Chem 288:16460-75
Labriola, Carlos A; Giraldo, Ana M Villamil; Parodi, Armando J et al. (2011) Functional cooperation between BiP and calreticulin in the folding maturation of a glycoprotein in Trypanosoma cruzi. Mol Biochem Parasitol 175:112-7
D'Alessio, Cecilia; Caramelo, Julio J; Parodi, Armando J (2010) UDP-GlC:glycoprotein glucosyltransferase-glucosidase II, the ying-yang of the ER quality control. Semin Cell Dev Biol 21:491-9
Villamil Giraldo, Ana María; Lopez Medus, Máximo; Gonzalez Lebrero, Mariano et al. (2010) The structure of calreticulin C-terminal domain is modulated by physiological variations of calcium concentration. J Biol Chem 285:4544-53
Soussilane, Pravina; Soussillane, Pravina; D'Alessio, Cecilia et al. (2009) N-glycan trimming by glucosidase II is essential for Arabidopsis development. Glycoconj J 26:597-607
Caramelo, Julio J; Parodi, Armando J (2007) How sugars convey information on protein conformation in the endoplasmic reticulum. Semin Cell Dev Biol 18:732-42
Caramelo, Julio J; Castro, Olga A; de Prat-Gay, Gonzalo et al. (2004) The endoplasmic reticulum glucosyltransferase recognizes nearly native glycoprotein folding intermediates. J Biol Chem 279:46280-5
Sousa, M C; Ferrero-Garcia, M A; Parodi, A J (1992) Recognition of the oligosaccharide and protein moieties of glycoproteins by the UDP-Glc:glycoprotein glucosyltransferase. Biochemistry 31:97-105